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1

Monitoring post-translational modification of proteins with allosteric ribozymes

Vaish, Narendra K., Dong, Fang, Andrews, Lori, Schweppe, Rebecca E., Ahn, Natalie G., Blatt, Lawrence, Seiwert, Scott D.

Journal:

Nature Biotechnology

Year:

2002

Language:

english

File:

PDF, 306 KB

english, 2002

2

Optimization of the multiple enzymatic activities of the hepatitis C virus NS3 protein

Shawn Misialek, Ravi Rajagopalan, Sarah K. Stevens, Leonid Beigelman, Scott D. Seiwert, Karl Kossen

Journal:

Analytical Biochemistry

Year:

2009

Language:

english

File:

PDF, 294 KB

english, 2009

3

HCV NS5B polymerase inhibitors 3: Synthesis and in vitro activity of 3-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-4-hydroxy-2H-quinolizin-2-one derivatives

Guangyi Wang, Laiguo Zhang, Xiaomin Wu, Debasis Das, Donald Ruhrmund, Lisa Hooi, Shawn Misialek, P.T. Ravi Rajagopalan, Brad O. Buckman, Karl Kossen, Scott D. Seiwert, Leonid Beigelman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 371 KB

english, 2009

4

High-Throughput Ribozyme-Based Assays for Detection of Viral Nucleic Acids

Karl Kossen, Narendra K Vaish, Vasant R Jadhav, Christopher Pasko, Hong Wang, Robert Jenison, James A McSwiggen, Barry Polisky, Scott D Seiwert

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 332 KB

english, 2004

5

Recent advances in drug discovery of benzothiadiazine and related analogs as HCV NS5B polymerase inhibitors

Debasis Das, Jian Hong, Shu-Hui Chen, Guangyi Wang, Leonid Beigelman, Scott D. Seiwert, Brad O. Buckman

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 752 KB

english, 2011

6

RNA aptamers as pathway-specific MAP kinase inhibitors

Scott D Seiwert, Theresa Stines Nahreini, Stefan Aigner, Natalie G Ahn, Olke C Uhlenbeck

Journal:

Chemistry & Biology

Year:

2000

Language:

english

File:

PDF, 597 KB

english, 2000

7

Global Transcriptional Profiling Demonstrates the Combination of Type I and Type II Interferon Enhances Antiviral and Immune Responses at Clinically Relevant Doses

Tan, Hua, Derrick, Jena, Hong, Jin, Sanda, Corneliu, Grosse, William M., Edenberg, Howard J., Taylor, Milton, Seiwert, Scott, Blatt, Lawrence M.

Journal:

Journal of Interferon & Cytokine Research

Year:

2005

Language:

english

File:

PDF, 287 KB

english, 2005

8

Inhibition and Binding Kinetics of the Hepatitis C Virus NS3 Protease Inhibitor ITMN-191 Reveals Tight Binding and Slow Dissociative Behavior

Rajagopalan, Ravi, Misialek, Shawn, Stevens, Sarah K., Myszka, David G., Brandhuber, Barbara J., Ballard, Joshua A., Andrews, Steven W., Seiwert, Scott D., Kossen, Karl

Journal:

Year:

2009

Language:

english

File:

PDF, 461 KB

english, 2009

9

Treatment of chronic hepatitis C patients with the NS3/4A protease inhibitor danoprevir (ITMN-191/RG7227) leads to robust reductions in viral RNA: A phase 1b multiple ascending dose study

Nicole Forestier, Dominique Larrey, Dominique Guyader, Patrick Marcellin, Régine Rouzier, Alain Patat, Patrick Smith, Williamson Bradford, Steven Porter, Lawrence Blatt, Scott D. Seiwert, Stefan Zeuze

Journal:

Journal of Hepatology

Year:

2011

Language:

english

File:

PDF, 651 KB

english, 2011

10

Monitoring protein modification with allosteric ribozymes

Narendra K Vaish, Karl Kossen, Lori E Andrews, Christopher Pasko, Scott D Seiwert

Journal:

Year:

2004

Language:

english

File:

PDF, 574 KB

english, 2004

11

Direct Visualization of Uridylate Deletion In Vitro Suggests a Mechanism for Kinetoplastid RNA Editing

Scott D Seiwert, Stefan Heidmann, Kenneth Stuart

Journal:

Year:

1996

Language:

english

File:

PDF, 274 KB

english, 1996

12

292 Synergistic effects of type 1 (infergen(R)) and type 2 (actimmune(R)) interferons in preclinical models of HCV: demonstration of potential efficacy

Lawrence M. Blatt, Hua Tan, Jin Hong, Jena Derrick, Scott Seiwert, Craig Day, John Morrey, William M. Grosse, Corneliu Sanda, Milton Taylor

Journal:

Year:

2003

Language:

english

File:

PDF, 279 KB

english, 2003

13

Immunomodulatory Activities of IFN-γ1b in Combination with Type I IFN: Implications for the Use of IFN-γ1b in the Treatment of Chronic HCV Infections

Wang, Tony, Blatt, Lawrence M., Seiwert, Scott D.

Journal:

Journal of Interferon & Cytokine Research

Year:

2006

Language:

english

File:

PDF, 2.49 MB

english, 2006

14

Left Ventricular Hypertrophy: A Study of the Accuracy of Current Electrocardiographic Criteria When Compared with Autopsy Findings in One Hundred Cases

SCOTT, R. C., SEIWERT, V. J., SIMON, D. L., MCGUIRE, J.

Journal:

Year:

1955

Language:

english

File:

PDF, 1.35 MB

english, 1955

15

Studies on the Use of Dioxyline Phosphate in the Treatment of Angina Pectoris

SCOTT, R. C., SEIWERT, V. J., FOWLER, N. O., MCGUIRE, J.

Journal:

Year:

1952

Language:

english

File:

PDF, 887 KB

english, 1952

16

Limited Functional Equivalence of Phylogenetic Variation in Small Nuclear RNA: Yeast U2 RNA with Altered Branchpoint Complementarity Inhibits Splicing and Produces a Dominant Lethal Phenotype

Loren Miraglia, Scott Seiwert, A. Haller Igel and Manuel Ares, Jr.

Journal:

Proceedings of the National Academy of Sciences

Year:

1991

Language:

english

File:

PDF, 1.05 MB

english, 1991

17

Effect of Interferon-gamma 1b in Cellular Models of Lung Fibrosis: Implications for the Treatment of Idiopathic Pulmonary Fibrosis (IPF)

Ozes, Osman, Tran, Tim, Wang, Tony, Stevens, Sarah, Seiwert, Scott, Blatt, Lawrence M.

Journal:

Year:

2004

Language:

english

File:

PDF, 186 KB

english, 2004

18

SPIE Proceedings [SPIE Microlithography 2004 - Santa Clara, CA (Sunday 22 February 2004)] Emerging Lithographic Technologies VIII - Status of Philips' extreme UV source

Pankert, Joseph, Mackay, R. Scott, Bergmann, Klaus, Klein, Juergen, Neff, Willi, Rosier, Oliver, Seiwert, Stefan, Smith, Christopher, Probst, Sven, Vaudrevange, Dominik, Siemons, Guido, Apetz, Rolf, J

Year:

2004

Language:

english

File:

PDF, 374 KB

english, 2004

19

PIRFENIDONE MEDIATES DIFFERENTIAL EFFECTS ON LIPOPOLYSACCHARIDE-INDUCED CYTOKINE EXPRESSION IN HUMAN PERIPHERAL MONONUCLEAR CELLS

Phillips, Roderick, Wang, Tony, Blatt, Lawrence M., Seiwert, Scott

Journal:

Year:

2005

Language:

english

File:

PDF, 137 KB

english, 2005

20

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 â¢ San Francisco, California - ()] C71. MAJOR IMPACT OF MICRO-RNA FUNCTION - Plasma MicroRNA Profile Of Idiopathic Pulmonary Fibrosis (IPF)

Kossen, Karl, Lim, Sharlene R., Qin, Xiaoli, Bradford, Williamson Z., Seiwert, Scott D.

Year:

2012

File:

PDF, 17 KB

2012